Heparin lithium is a chemical substance with a white to almost white powder appearance. There was no statistically significant difference in the detection results of TP, ASO, UA, ALT, Mg, Cl, TC, CRP between heparin lithium anticoagulant plasma and serum (P>0.05). There was a statistically significant difference in the detection results of HBD, LDH, and TChemicalbookBA between heparin lithium anticoagulant plasma and serum (P<0.05). Therefore, except for HBD, LDH, and TBA, the correlation between heparin lithium anticoagulant plasma and serum is good. Therefore, the feasibility of using heparin lithium anticoagulant plasma instead of serum in daily life testing is high, and it can be used as an important detection method. The preparation of heparin lithium has been publicly disclosed in China through ion equilibrium exchange method. Some of the process steps of this method require low-temperature conditions (below 10 ℃) operation, which requires high requirements for material and environmental temperature control, and requires significant investment in hardware facilities; This method operates under strong acidic conditions (pH 1.5) in the deproteinization process, resulting in significant loss of heparin activity (heparin solution is unstable in low pH environments and easily degrades and inactivates), which affects the final activity yield and potency, and the operability is not strong; This method adopts ultrafiltration concentration and separation technology, which is expensive in ultrafiltration equipment and requires significant hardware investment; The ion balance exchange method used in this method involves the continuous intervention of high concentration lithium ions to achieve the conversion of heparin sodium to heparin lithium, which cannot guarantee the sufficiency and continuous stability of dynamic ion balance conversion.